Melanomas.

ICONOGRAFIA TEMÁTICA

Melanomas.

Iconografia Ml 81 -

Descoberto em seus estágios iniciais, o melanoma é quase sempre curável. Porém, se diagnosticado tardiamente, tende a se espalhar para outras partes do corpo em um processo chamado metástase. Ele é bem mais raro que os carcinomas baso e espinocelular, mas é uma doença bem mais grave. A cura desde tipo de câncer está ligada à descoberta precoce, seu diagnóstico é clínico, mas a biopsia é a forma de confirmação, além da dermatoscopia que também é um exame laboratorial.

Iconografia Ml 82 –A/B

A característica da mancha ou nódulo formado por este tipo de câncer, formato e bordas irregulares, médicos costumam comparar com um mapa geográfico de um território litorâneo, isso porque a intensidade da mancha pode variar pra mais clara e escura em certos pontos da mancha. Além de surgir sangramento, coceira e inflamação.

Iconografia Ml 83 Melanoma da mucosa bucal Primária. Afetando a gengiva e mucosa no lábio inferior. Banco de Dados Iconográficos e casos clínicos referentes ao melanoma. Casos clínicos e terapia farmacológica. https://www.nlm.nih.gov/

MELANOMA - Bibliografia recomendada para estudos aprofundados em relação ao tema focado.

Pathology of tumors of the oral cavity.Batsakis JG. in Thawley SE, Panje WR, Batsakis JG, et al (eds): Comprehensive Management of Head and Neck Tumors. Philadelphia, PA, Saunders,1999, pp 651-655.

Malignant melanoma of the skin of the head and neck Ballantyne AJ An analysis of 405 cases Am J Surg PMID 5507326

The pathology of head and neck tumors: mucosal melanomas, part 13 Batsakis JG, Regezi JA, Solomon AR, Rice DH Head Neck Surg 1982 May-Jun;4(5):404-18 PMID 7096100

The immunohistochemical identification of human oral mucosal melanocytes Barrett AW, Raja AM Arch Oral Biol 1997 Jan;42(1):77-81 PMID 9134118

A case of monthly unipolar psychotic depression with suicide attempt by self-burning: selective response to bupropion treatment Schenck CH, Mandell M, Lewis GM Compr Psychiatry 1992 Sep-Oct;33(5):353-6 PMID 1395556

Primary mucosal malignant melanoma of the head and neck Patel SG, Prasad ML, Escrig M, Singh B, Shaha AR, Kraus DH, Boyle JO, Huvos AG, Busam K, Shah JP Head Neck 2002 Mar;24(3):247-57 PMID 11891956

Prognostic factors for malignant melanoma of the squamous mucosa of the head and neck

Prasad ML, Patel S, Hoshaw-Woodard S, Escrig M, Shah JP, Huvos AG, Busam KJ  Am J Surg Pathol 2002 Jul;26(7):883-92 PMID 12131155

Primary malignant melanoma of the oral mucosa Rapidis AD, Apostolidis C, Vilos G, Valsamis S J Oral Maxillofac Surg 2003 Oct;61(10):1132-9 PMID 14586846

Exon 15 BRAF mutations are uncommon in melanomas arising in nonsun-exposed sites

Cohen Y, Rosenbaum E, Begum S, Goldenberg D, Esche C, Lavie O, Sidransky D, Westra WH

Clin Cancer Res 2004 May 15;10(10):3444-7

PMID 15161700

Expression and significance of cancer testis antigens in primary mucosal melanoma of the head and neck Prasad ML, Jungbluth AA, Patel SG, Iversen K, Hoshaw-Woodard S, Busam KJ Head Neck 2004 Dec;26(12):1053-7 PMID 15515159

Primary mucosal melanoma of the head and neck: a proposal for microstaging localized, Stage I (lymph node-negative) tumors Prasad ML, Patel SG, Huvos AG, Shah JP, Busam KJ

Cancer 2004 Apr 15;100(8):1657-64 PMID 15073854

Distinct sets of genetic alterations in melanoma Curtin JA, Fridlyand J, Kageshita T, Patel HN, Busam KJ, Kutzner H, Cho KH, Aiba S, Bröcker EB, LeBoit PE, Pinkel D, Bastian BC N Engl J Med 2005 Nov 17;353(20):2135-47

Melanoma of the oral mucosa  González-García R, Naval-Gías L, Martos PL, Nam-Cha SH, Rodríguez-Campo FJ, Mu@ntilde;oz-Guerra MF, Sastre-Pérez J Clinical cases and review of the literature Med Oral Patol Oral Cir Bucal PMID 15876972

 Incidence of noncutaneous melanomas in the U McLaughlin CC, Wu XC, Jemal A, Martin HJ, Roche LM, Chen VW S Cancer PMID 15651058

Somatic activation of KIT in distinct subtypes of melanoma Curtin JA, Busam K, Pinkel D, Bastian BC J Clin Oncol 2006 Sep 10;24(26):4340-6 PMID 16908931

Anatomic site-specific patterns of gene copy number gains in skin, mucosal, and uveal melanomas detected by fluorescence in situ hybridization Glatz-Krieger K, Pache M, Tapia C, Fuchs A, Savic S, Glatz D, Mihatsch M, Meyer P Virchows Arch 2006 Sep;449(3):328-33 PMID 16523260

Comprehensive analysis of the p53 status in mucosal and cutaneous melanomas Gwosdz C, Scheckenbach K, Lieven O, Reifenberger J, Knopf A, Bier H, Balz V Int J Cancer 2006 Feb 1;118(3):577-82 PMID 16094622

Primary malignant melanoma of the oral mucosa Chidzonga MM, Mahomva L, Marimo C, Makunike-Mutasa R J Oral Maxillofac Surg 2007 Jun;65(6):1117-20 PMID 17517294

Oral malignant melanoma: a review of the literature Meleti M, Leemans CR, Mooi WJ, Vescovi P, van der Waal I Oral Oncol 2007 Feb;43(2):116-21 PMID 16931116

Biochemotherapy in patients with advanced head and neck mucosal melanoma Bartell HL, Bedikian AY, Papadopoulos NE, Dett TK, Ballo MT, Myers JN, Hwu P, Kim KB Head Neck 2008 Dec;30(12):1592-8 PMID 18798304

What is the role of radiotherapy in the treatment of mucosal melanoma of the head and neck? Crit Rev Oncol Hematol Krengli M, Jereczek-Fossa BA, Kaanders JH, Masini L, Beldì D, Orecchia R 2008 Feb;65(2):121-8 Epub 2007 Sep 5 PMID 17822915

 PNL2 melanocytic marker in immunohistochemical evaluation of primary mucosal melanoma of the head and neck Morris LG, Wen YH, Nonaka D, DeLacure MD, Kutler DI, Huan Y, Wang BY Head Neck 2008 Jun;30(6):771-5 PMID 18228523

C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma Rivera RS, Nagatsuka H, Gunduz M, Cengiz B, Gunduz E, Siar CH, Tsujigiwa H, Tamamura R, Han KN, Nagai N

Virchows Arch 2008 Jan;452(1):27-32 PMID 18066592

Mucosal melanoma of the head and neck

Wagner M, Morris CG, Werning JW, Mendenhall WM Am J Clin Oncol 2008 Feb;31(1):43-8 PMID 18376227

GAB2 amplifications refine molecular classification of melanoma Chernoff KA, Bordone L, Horst B, Simon K, Twadell W, Lee K, Cohen JA, Wang S, Silvers DN, Brunner G, Celebi JT Clin Cancer Res 2009 Jul 1;15(13):4288-91 PMID 19509136

Primary oral melanoma: population-based incidence Sortino-Rachou AM, Cancela Mde C, Voti L, Curado MP Oral Oncol 2009 Mar;45(3):254-8 PMID 18675580

The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM Edge SB, Compton CC

Ann Surg Oncol 2010 Jun;17(6):1471-4

PMID 20180029

Malignant melanoma: molecular cytogenetics and their implications in clinical medicine

Junkins-Hopkins JM J Am Acad Dermatol 2010 Aug;63(2):329-32 PMID 20633801

NRAS and BRAF mutation frequency in primary oral mucosal melanoma Buery RR, Siar CH, Katase N, Gunduz M, Lefeuvre M, Fujii M, Inoue M, Setsu K, Nagatsuka H Oncol Rep 2011 Oct;26(4):783-7 PMID 21750866

Review: mucosal melanoma of the head and neck Gavriel H, McArthur G, Sizeland A, Henderson M Melanoma Res 2011 Aug;21(4):257-66 PMID 21540752

Mucosal melanoma of the head and neck: predictors of prognosis Shuman AG, Light E, Olsen SH, Pynnonen MA, Taylor JM, Johnson TM, Bradford CR Arch Otolaryngol Head Neck Surg 2011 Apr;137(4):331-7 PMID 21502471

Head and neck mucosal malignant melanoma: clinicopathologic correlation with contemporary review of prognostic indicators

Kerr EH, Hameed O, Lewis JS Jr, Bartolucci AA, Wang D, Said-Al-Naief N Int J Surg Pathol 2012 Feb;20(1):37-46 PMID 21862490

Primary mucosal melanomas: a comprehensive review Mihajlovic M, Vlajkovic S, Jovanovic P, Stefanovic V Int J Clin Exp Pathol 2012;5(8):739-53 PMID 23071856

Prognostic significance of regulators of cell cycle and apoptosis, p16(INK4a), p53, and bcl-2 in primary mucosal melanomas of the head and neck Prasad ML, Patel SG, Shah JP, Hoshaw-Woodard S, Busam KJ Head Neck Pathol 2012 Jun;6(2):184-90 PMID 22160615

Adhesion molecules in primary oral mucosal melanoma: study of claudins, integrins and immunoglobulins in a series of 35 cases Bologna SB, Nico MM, Hsieh R, Coutinho-Camillo CM, Buim ME, Fernandes JD, Sangueza M, Soares FA, Lourenço SV Am J Dermatopathol 2013 Jul;35(5):541-54 PMID 23715077

The CDKN2A and MAP kinase pathways: molecular roads to primary oral mucosal melanoma Hsieh R, Nico MM, Coutinho-Camillo CM, Buim ME, Sangueza M, Lourenço SV Am J Dermatopathol 2013 Apr;35(2):167-75 PMID 23000904

Update on primary head and neck mucosal melanoma López F, Rodrigo JP, Cardesa A, Triantafyllou A, Devaney KO, Mendenhall WM, Haigentz M, Strojan P, Pellitteri PK, Bradford CR, Shaha AR, Hunt JL, de Bree R, Takes RP, Rinaldo A, Ferlito A Head Neck 2014 Sep 20 PMID 25242350